Inhibition of Mycobacterial Growth by Plumbagin Derivatives

REOVIRUS GROWTH INHIBITION BY ROTAVIRUS FOLLOWING COINFECTION

Role of iron in Nramp1-mediated inhibition of mycobacterial growth.

Innate resistance to mycobacterial growth is mediated by a gene, Nramp1. We have previously reported that Nramp1 mRNA from macrophages of Mycobacterium bovis BCG-resistant (Bcgr) mice is more stable than Nramp1 mRNA from macrophages of BCG-susceptible (Bcgs) mice. Based on these observations and on reports that show that the closely related Nramp2 gene is a metal ion transporter, we evaluated t...

Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium.

Mycobacterium tuberculosis invades alveolar epithelial cells as well as macrophages. However, the role of alveolar epithelial cells in the host defense against M. tuberculosis remains unknown. In this study, we report that lipocalin 2 (Lcn2)-dependent inhibition of mycobacterial growth within epithelial cells is required for anti-mycobacterial innate immune responses. Lcn2 is secreted into the ...

Epithelium Mycobacterial Growth in Alveolar Lipocalin 2-Dependent Inhibition of

Mycobacterial growth inhibition is associated with trained innate immunity.

The lack of defined correlates of protection hampers development of vaccines against tuberculosis (TB). In vitro mycobacterial outgrowth assays are thought to better capture the complexity of the human host/Mycobacterium tuberculosis (Mtb) interaction. Here, we used a mycobacterial growth inhibition assay (MGIA) based on peripheral blood mononuclear cells to investigate the capacity to control ...